Original Article
Comparison of Measurement of Intraocular Pressure between Goldmann
Applanation Tonometer and Non-Contact Air Puff Tonometer
Attaullah Shah Bukhari,
Abdul Haleem Mirani, Muhammad Ali Shar, Shahid Jamal
Siddiqui
Liaquat Ali Shah
Pak J Ophthalmol 2018, Vol. 34, No. 1
. . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . .
See
end of article for authors
affiliations …..……………………….. Correspondence
to: Attaullah Shah Bukhari Flat No: B2 Doctor Residence Civil Hospital, Khairpur Email: drattaullahbukhari@yahoo.com |
Purpose: To compare measurement of intraocular pressure between Goldmann
Applanation Tonometer and Non-Contact Air Puff Tonometer. Study Design: Clinical Observational Study. Place and Duration of Study: This study was carried out at outpatient Department of
Ophthalmology, Khairpur Medical College Hospital, Khairpur from January 2017
to March 2017. Material and Methods: In this study intra ocular pressures of 400 eyes of 200
patients, Male 125 (250 eyes) and Female 75 (150 eyes) with age ranging from 20
to 70 years, were measured by Goldmann Applanation Tonometer (GAT) and
Non-Contact Air Puff Tonometer (APT), results and differences were noted. Results: The mean IOP was 16 mm Hg (SD = 6 mm Hg) measured by APT and 13 mm Hg (SD = 3 mm Hg)
measured by GAT. The calculated difference between APT and GAT was 3 ± 2.5 mm
Hg. Pressure taken by APT was slight high (i.e. around 3 mm Hg). Conclusion: Air Puff tonometry gives slightly higher results (about 3 mm Hg)
but is safe and easy than Goldmann Applanation tonometer. There is no fear of
spread of infection and can be used easily in mass screening programs. Key
Words: Goldmann Applanation Tonometer, Air-Puff non-contact Tonometer, Intraocular
pressure, Glaucoma. |
Increase in intraocular pressure is one of the risk factors in the development
and progression of glaucoma1-2. Control and reduction in IOP is the
main goal in treatment of glaucoma3. There are various methods to
measure IOP like Schoitz tonometer, Goldmann applanation tonometer (GAT),
Perkins applanation tonometer, air puff non-contact tonometer, Tonopen, Pascal
dynamic contour tonometer, I Care tonometer. GAT is worldwide used for measurement
of IOP and is Gold standard.4
GAT has many factors to affect its accuracy
like thickness of central cornea5, however normal central corneal
thickness (CCT) has been documented from 427µm to 670 µm6, if we
consider 520 µm as standard7. If central corneal thickness is more
than 520 µm, it overestimates IOP and if it is thinner than 520 µm, it underestimates8-9.
Various corrective factors have been proposed ranging from 0.19 to 0.7 mm for each
10 µm difference in central corneal thickness from mean value8-10. This
relationship between CCT and IOP has clinical implications especially in the
diagnosis of ocular hypertension (OHT). Researchers have documented thicker CCT
in OHT subjects and suggested that some are misclassified due to thicker cornea
producing an artificially raised IOP11,12,13. Conversely, subjects
with thicker corneas have been shown to have a lower rate of progression to
glaucomatous damage14.
GAT has double prism and
3.06 mm area of cornea is applanated using Imbert Fick principle. It is done
under local anesthesia and also requires slit lamp.15APT is based on principle of applanation,
but instead of using prism, the central part of the cornea is flattened by a
jet of air. The time acquired to sufficiently flatten the cornea relates
directly to the level of IOP. In APT, there is no need of local anesthesia and no
contact with cornea, so it prevents spread of infection. It may be portable and
non-portable16. This study was conducted to find out the accuracy of
APT to the gold standard GAT.
MATERIAL AND METHODS
A comparative randomized study conducted in
the ophthalmology department of Khairpur Medical College Hospital. There were 400
eyes of 200 patients (125 males and 75 females) with age ranging from 20 to 70
years. Adult co-operative patients visiting the outpatient department were
included. Uncooperative patients and patients with severe vision loss, who were
unable to keep fixation of eye ball and patients with history of refractive
surgery were excluded from the study.
IOP using APT was taken
using tonometer NCT-10 SHIN-NIPPON (made in Japan) and later IOP was measured using
GAT with CSO model: A 900 tonometer (made: in Italy). Proparacaine eye drops were
put in eyes for anesthesia and fluorescein strips were used for staining of
cornea.
RESULTS
The study included 400
eyes of 200 patients i.e. males 125 (250 eyes) and females 75 (150 eyes), with
mean age of 54.12 ± 13.56 years (range 20 – 70 years (table 1). In 40 (10%) eyes,
IOP taken by APT was equal to GAT. In 20 eyes (5%), IOP with APT was below GAT
and in 340 (85%) eyes IOP was higher than GAT. The mean IOP measured by APT was
16 ± 6 mm Hg and mean IOP measured by GAT was 13 ± 3 mm Hg. The calculated difference
between APT and GAT was 3 ± 2.5 mm Hg (table 2).
Table 1: Characteristics of Study
Population (n = 400).
Age in Years |
|
Range |
20 – 70 years (mean 54.12 ± 13.56
years) |
Male |
125 (250 eyes) |
Female |
75 (150 eyes) |
Table 2: IOP values measured by GAT as related to IOP measured by APT.
IOP Measurement by Air puff Tonometer |
Patients % |
Equal to GAT measurement |
40 (10%) |
Higher than GAT measurement |
340 (85%) |
Lower than GAT Measurement |
20 (5%) |
DISCUSSION
Air puff tonometer and Goldman applanation
tonometer are common devices to measure IOP. Pressure recorded by AP tonometer
is slightly higher. Many studies have compared IOP between GAT and APT17-18.
Friat et al17 study revealed that GAT results are slight lower than non-contact
tonometer. Martinez-de-la-casa et al19 concluded that results of AP
tonometer were higher than GAT. Tonnuet al20 showed that difference
in IOP between two methods was 0.7 mm Hg. Rao21 states that when IOP
was < 20 mm Hg, it was more accurate with APT. Lagerlof21
revealed that IOP > 20 and 30 mm Hg measured by APT is unreliable.
A study was conducted by
Bang et al, comparing intraocular pressures, measured by three different
non-contact tonometers and Goldmann applanation tonometer, for non-glaucomatous
subjects. They stated that there was statistically significant correlation
between three non-contact tonometers and Goldmann applanation tonometer. They said that IOP measured with Nidek NT-530P
was lower than GAT while IOP taken by Topcan CT-IP and canon T x 20P was higher
than Goldmann applanation tonometer22. Study conducted by Javed
Ahmed et al revealed that Goldmann applanation tonometer was more accurate but
air puff tonometer was good and easy for screening purposes23. Study
conducted by Josphine Wachtl et al proved that IOP taken by GAT in thin corneas
and advanced glaucoma gave unpredictable measurement errors24. Study
conducted by Sana Naeem et al, showed that measurement of intraocular pressure
by three different tonometers was comparable with good relation in normal
adults. APT can be used as a good screening device to rule out glaucoma in patients25.
Study conducted by Dibaji et al stated that non-contact air puff tonometer was
quick for screening purposes but measurement should be confirmed by Goldmann
applanation tonometer26. Study conducted by Toprak et al showed
that IOP values obtained by NCT 1 (non-contact tonometer with 1-puff) and NCT 3
(3- puffs) appeared to be similar with GAT measurement. Wide range of LoA might limit the use of this
NCT (both 1-puff and 3-puffs) and GAT interchangeably in primary open angle
glaucoma patients27. Sood A and his colleague studied the clinical estimation of
intraocular pressure with a non-contact tonometer and Goldman applanation
tonometer as a tool for mass screening and its correlation with central corneal
thickness. Both the methods of IOP measurement showed positive co-relation with
central corneal thickness. The NCT was more influenced by CCT than GAT for
every 10 micron CCT change. The IOP change expected with NCT was 0.47 mm Hg and
GAT was 0.29 mm Hg28.
CONCLUSION
IOP with APT is slight
higher about 3 mm Hg but is safe and easy than GAT tonometry. There is no fear
of spread of infection and it can be used in mass screening program
Author’s Affiliation
Dr.
Attaullah Shah Bukhari
Assistant
Professor
Department
Of Ophthalmology
Khairpur
Medical College Khairpur Mir’s.
Dr.
Abdul Haleem Mirani
Assistant
Professor
Department
of Ophthalmology
GMMC
Sukkur
Dr.
Muhammad Ali Shar
Ophthalmologist
KMC Hospital
Khairpur
Mir’s
Prof.
Shahid Jamal Siddiqui
Head
department of Ophthalmology
Khairpur
Medical College Khairpur Mir’s
Dr.
Liaquat Ali Shah
Chief
ophthalmologist
Civil
hospital khairpur
Role of Author’s
Dr.
Attaullah Shah Bukhari
Substantial
and Direct Intellectual Conception, Design, Analysis, Collection and
Interpretation of Data.
Dr.
Abdul Haleem Mirani
Collection
of Data, and references.
Dr.
Muhammad Ali Shar
Collection
of Data, and references.
Prof.
Shahid Jamal Siddiqui
Intellectual
Conception, Design, Interpretation and Final Review.
Dr.
Liaquat Ali Shah
Collection
of Data, and references.
REFERENCES
1.
Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: A Randomized Trial
Determines That Topical Ocular Hypotensive Medication Delays or Prevents the
Onset of Primary Open-Angle Glaucoma. Arch Ophthalmol. 2002; 120: 701-13.
2.
Heijl A, Leske MC,
Bengtsson B, et al. Reduction of intraocular pressure and glaucoma
progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol
2002; 120: 1268–79.
3.
Realini T, Weinreb RN, Hobbs G. Correlation of intraocular pressure measured with goldmann and dynamic
contour tonometry in normal and glaucomatous eyes. J Glaucoma, 2009; 18 (2):
119-23.
4.
Halkiadakis I, Patsea E, Chatzimichali K, et al. Comparison of dynamic contour tonometry with goldmann applanation tonometry in glaucoma practice.
Acta Ophthalmol. 2009; 87: 323-8.
5.
Whitacre MM, Stein R.
Sources of error with use of Goldmann-type tonometers. Surv Ophthalmol. 1993;
38 (1): 1–30.
6.
Hansen FK. A
clinical study of the normal human central corneal thickness. Acta
Ophthalmologica. 1971; 49 (1): 82–99.
7.
Goldmann V, Schmidt T. Uber Applanations tonometrie. Ophthalmologica. 1957; 134: 221–42.
8.
Johnson M, Kass MA, Moses RA, & Grodzki WJ. Increased corneal thickness simulating elevated intraocular
pressure. Arch Ophthalmol. 1978; 96: 664-5.
9.
Doughty MJ, Zaman ML.
Human corneal thickness and its impact on intraocular pressure measures: a
review and meta-analysis approach. Surv Ophthalmol. 2000; 44: 367-408.
10.
Wolfs RC, Klaver CC, Vingerling JR, Grob-bee DE, Hofman A & de
Jong PT. Distribution of corneal
central thickness and its association with intraocular pressure: The Rotterdam
Study. Am J Ophthalmol. 1997; 123: 767-72.
11.
Copt RP, Thomas R, Mermoud A. Corneal thickness in ocular hypertension, primary open-angle
glaucoma, and normal tension glaucoma. Arch Ophthalmol. 1999; 117 (1): 14–6.
12.
Bron AM, Creuzot-GarcherC, Goudeau-Boutillon S, d’Athis P. Falsely elevated intraocular pressure due to increasedcentral
corneal thickness. Graefes Arch Clin Exp Ophthalmol. 1999; 237 (3): 220–4.
13.
Herndon LW, Choudhri SA, Cox T, Damji KF, Shields MB, Allingham
RR. Central corneal thickness in
normal, glaucomatous, and ocular hypertensive eyes. Arch Ophthalmol. 1997; 115 (9):
1137–41.
14.
Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ,
Johnson CA et al. The Ocular Hypertension
Treatment Study: baseline factors that predict the onset of primary open-angle
glaucoma. Arch Ophthalmol. 2002; 120 (6): 714–20.
15.
Morrison JC, Pollack IP, editors. Glaucoma Science and
Practice. New York, NY: Thieme Medical Publishers; 2003: 60–4.
16.
Kanski JJ, Bowling B.
Clinical Ophthalmology: A Systematic
Approach, 7th ed. Philadelphia: Elsevier; 2011: 315–644.
17.
Firat PG, Cankaya C, Doganay S, et al. The influence of soft contact lenses on the intraocular pressure
measurement. Eye (Lond). 2012; 26
(2): 278–82.
18.
Lagerlöf O. Airpuff
tonometry versus applanation tonometry. Acta
Ophthalmol (Copenh). 1990; 68 (2): 221-4.
19.
Martinez-de-la-Casa JM, Jimenez-Santos M, Saenz-Frances F et al. Performance of the rebound, noncontact and Goldmann applanation
tonometers in routine clinical practice. Acta
Ophthalmol. 2011; 89 (7): 676–80.
20.
Tonnu PA, Ho T, Sharma K, White E, Bunce C, Garway-Heath D. A comparison of four methods of tonometry: method agreement and
interobserver variability. Br J
Ophthalmol. 2005; 89 (7): 847–50.
21.
Rao BS.
Clinical evaluation of the non-contact tonometer and comparison with Goldmann
applanation tonometer. Indian J
Ophthalmol. 1984; 32 (5): 432–4.
22.
Seung Pil Bang Chong Eun Lee and Yu Cheol Kim. BMC Ophthalmology, 2017; 17: 199.
23.
Javied A, Muhammad RK, Muhammad NA, Tariq MA, Qazi ZA. Accuracy of IOP Measured By Non-Contact (Air – Puff) Tonometer
Compared with Goldmann Applanation Tonometer Pak J Ophthalmol 2014, Vol. 30,
No. 1.
24.
Wachtl J, Harms MT, Frimmel S, Roos M, Kniestedt C Tonometry. Uncorrected and Corrected Goldmann Applanation Tonometry, and
Stage of Glaucoma JAMA Ophthalmol. 2017; 135 (6): 601-608.
25.
Nadeem S, Naeem BA, Tahira R, Khalid S, Hannan A. Comparison of Goldmann Applanation, Diaton Transpalpebral and Air
Puff Tonometers, Pak J Ophthalmol. 2015, Vol. 31, No. 1: 33-39.
26.
Dibaji M, Shaikh RM.
Study of Accuracy of Intraocular Pressure measured by non-contact (air puff)
Tonometer confirmed by Goldmann Applanation Tonometer PJMHS. JUL – SEP 2016; Vol.
10, No. 3: 972-974.
27.
Toprak I, Kilic D. Effects of puff times on intraocular
pressure agreement between non-contact and Goldmann applanation tonometers. Guoji Yanke Zazhi (Int Eye Sci.) 2014; 14 (7): 1186-1189.
28.
Sood A, Nazir A, Runyal
F, Mohiudin S, Sadiq T. Clinical estimation of
intraocular pressure with a non-contact tonometer and Goldman applanation
tonometer as a tool for mass screening and its correlation with central corneal
thickness: A comparative hospital based study GJMEDPH. 2015; Vol. 4, Issue 4.